Takeshi Watanabe Selected Research

Histamine (Histamine Dihydrochloride)

1/2015	CCL22/Macrophage-derived Chemokine Expression in Apolipoprotein E-deficient Mice and Effects of Histamine in the Setting of Atherosclerosis.
9/2013	Histamine receptors expressed in circulating progenitor cells have reciprocal actions in ligation-induced arteriosclerosis.
8/2010	Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice.
11/2009	Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis.
4/2009	[Role of histamine and histamine receptors in the pathogenesis of malaria].
2/2008	Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease.
6/2006	The H1 histamine receptor regulates allergic lung responses.
1/2006	Increased susceptibility to diet-induced obesity in histamine-deficient mice.
9/2004	Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity.
9/2004	Inducible histamine protects mice from P. acnes-primed and LPS-induced hepatitis through H2-receptor stimulation.

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Takeshi Watanabe Research Topics

Disease

31	Neoplasms (Cancer) 01/2022 - 01/2002
10	Inflammation (Inflammations) 01/2022 - 06/2006
7	Neoplasm Metastasis (Metastasis) 01/2022 - 10/2003
7	Carcinoma (Carcinomatosis) 01/2020 - 06/2002
6	Adenocarcinoma 01/2022 - 01/2003
5	Ischemia 01/2022 - 01/2019
5	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2011 - 05/2008
4	Necrosis 04/2022 - 04/2015
4	Rheumatoid Arthritis 02/2016 - 01/2005
3	Pain (Aches) 05/2022 - 06/2002
3	Reperfusion Injury 01/2022 - 07/2015
3	Colonic Neoplasms (Colon Cancer) 09/2021 - 12/2012
3	Otitis Media 02/2021 - 01/2017
3	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 02/2021 - 01/2017
3	Hemorrhage 01/2021 - 09/2014
3	Bacterial Infections (Bacterial Infection) 01/2011 - 08/2004
3	Infections 11/2010 - 02/2002
3	Hepatocellular Carcinoma (Hepatoma) 12/2009 - 08/2005
3	Stomach Neoplasms (Stomach Cancer) 05/2006 - 12/2002
3	Body Weight (Weight, Body) 01/2006 - 12/2002
3	Hypersensitivity (Allergy) 03/2003 - 05/2002
2	Hypoxia (Hypoxemia) 04/2022 - 10/2020
2	Thrombosis (Thrombus) 01/2021 - 01/2006
2	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 07/2003
2	Burning Mouth Syndrome (Syndrome, Burning Mouth) 01/2019 - 09/2018
2	Hearing Loss (Hearing Impairment) 10/2018 - 01/2017
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/2018 - 01/2013
2	Colitis 07/2018 - 01/2013
2	Poisoning 12/2017 - 10/2014
2	Adenoma (Adenomas) 04/2017 - 06/2013
2	Lung Neoplasms (Lung Cancer) 03/2015 - 01/2002
2	Atopic Dermatitis (Atopic Eczema) 06/2014 - 01/2014
2	Stroke (Strokes) 07/2013 - 09/2002
2	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 09/2012 - 12/2004
2	Ovarian Neoplasms (Ovarian Cancer) 09/2012 - 03/2007
2	Cysts 06/2011 - 12/2009
2	Werner Syndrome (Werner's Syndrome) 02/2011 - 04/2009
2	Sepsis (Septicemia) 01/2011 - 08/2004
2	Cystitis 12/2009 - 10/2009
2	Malaria 04/2009 - 02/2008
2	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 08/2006 - 10/2005
2	Pneumonia (Pneumonitis) 06/2006 - 08/2004
2	Obesity 01/2006 - 09/2004
2	Overactive Urinary Bladder (Overactive Bladder) 05/2005 - 08/2004
2	Cholangiocarcinoma 10/2003 - 06/2002
2	Sneezing 08/2002 - 05/2002

Drug/Important Bio-Agent (IBA)

20	Histamine (Histamine Dihydrochloride)FDA Link 01/2015 - 04/2002
19	AntigensIBA 03/2007 - 01/2002
11	Proteins (Proteins, Gene)FDA Link 07/2018 - 06/2002
8	Histamine Receptors (Histamine Receptor)IBA 09/2013 - 07/2002
7	CytokinesIBA 02/2016 - 10/2003
5	Histidine DecarboxylaseIBA 11/2009 - 06/2003
4	Pharmaceutical PreparationsIBA 05/2022 - 08/2004
4	Biomarkers (Surrogate Marker)IBA 12/2021 - 12/2006
4	ChemokinesIBA 07/2018 - 10/2003
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2018 - 08/2004
4	EnzymesIBA 10/2014 - 01/2003
4	Biological ProductsIBA 12/2012 - 12/2006
4	Messenger RNA (mRNA)IBA 06/2006 - 09/2004
4	Monoclonal AntibodiesIBA 10/2003 - 01/2002
3	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 02/2021 - 01/2017
3	Glucose (Dextrose)FDA LinkGeneric 12/2017 - 03/2003
3	Peptides (Polypeptides)IBA 01/2017 - 08/2005
3	CollagenIBA 03/2015 - 01/2006
3	Streptozocin (Streptozotocin)FDA Link 12/2009 - 03/2002
3	AminesIBA 04/2009 - 03/2003
3	Cholinergic Antagonists (Anticholinergics)IBA 12/2007 - 08/2004
3	Fas Ligand Protein (Fas Ligand)IBA 06/2005 - 01/2003
3	Histamine H1 Receptors (Histamine H1 Receptor)IBA 09/2004 - 05/2002
2	Myeloblastin (Proteinase 3)IBA 02/2021 - 01/2017
2	Peroxidase (Myeloperoxidase)IBA 02/2021 - 01/2017
2	Amitriptyline (Elavil)FDA LinkGeneric 01/2019 - 09/2018
2	Chemokine ReceptorsIBA 07/2018 - 10/2003
2	LigandsIBA 07/2018 - 01/2002
2	SolutionsIBA 10/2014 - 05/2002
2	Small Interfering RNA (siRNA)IBA 05/2013 - 08/2005
2	DNA (Deoxyribonucleic Acid)IBA 09/2012 - 10/2003
2	Scavenger Receptors (Scavenger Receptor)IBA 06/2011 - 12/2009
2	RecQ HelicasesIBA 02/2011 - 04/2009
2	Telomerase (Telomerase Reverse Transcriptase)IBA 02/2011 - 04/2009
2	Superoxide Dismutase-1IBA 01/2011 - 05/2008
2	Cimetidine (Biomet)FDA LinkGeneric 01/2011 - 08/2006
2	GlypicansIBA 12/2009 - 08/2009
2	VimentinIBA 12/2009 - 10/2005
2	Amino Acids FDA Link 10/2009 - 03/2004
2	ChitinasesIBA 05/2009 - 04/2003
2	Immunoglobulin G (IgG)IBA 07/2008 - 12/2004
2	oxybutynin (Tavor)FDA LinkGeneric 12/2007 - 08/2004
2	Complementary DNA (cDNA)IBA 05/2006 - 12/2002
2	HLA-A*02:01 antigenIBA 05/2006 - 08/2005
2	LipopolysaccharidesIBA 09/2004 - 08/2004
2	talabostatIBA 08/2004 - 09/2003
2	Tumor Biomarkers (Tumor Markers)IBA 10/2003 - 01/2002

Therapy/Procedure

9	Therapeutics 01/2022 - 08/2004
4	Immunotherapy 01/2018 - 08/2005
3	Drug Therapy (Chemotherapy) 01/2022 - 12/2017
3	Ligation 10/2020 - 01/2011
3	Oral Administration 01/2018 - 08/2004
2	Colectomy 09/2021 - 01/2020
2	Nephrectomy 11/2011 - 12/2002